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7.6.6 Functional requirements

Although magnetic resonance imaging (MRI) has been created as a useful tool for detecting tumours its ability to diagnose very small tumours is restricted by the way to detect the difference between malignant and normal tissue. To solve this sensitivity problem nanoparticles that are targeted to tumours and loaded with magnetic metal ions such as iron are used. The metal ions act as signal amplifiers.

Resovist® consists of superparamagnetic iron oxide (SPIO) nanoparticles coated with carboxydextran, which are accumulated by phagocytosis in cells of the reticuloendothelial system (RES) of the liver. Feridex® works in the same way.

GastroMARK® is an aqueous suspension of silicone-coated, superparamagnetic iron oxide, intended for oral administration.

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7.6.6 Functional requirements