report
7.4.8 Product examples

Ostim®

Ostim® is a ready to use, injectable, paste-like osseous matrix. It consists of fully synthetic, nanoparticulate and phase-pure Hydroxylapatit. Ostim® is used for the replenishment or reconstruction of osseous defects. The paste can be applied directly or by means of applicators in the bony defect. Ostim® does not harden while mixing with blood or cancellous bone and is therefore very well suited for the volume increase of autogenic or homologous material. The volume stability of Ostim® 35 allows resistance to bleeding pressure, while its viscosity allows application in close contact with the bone. Ostim® is suitable for the defective replenishment of fractures in the spongy area. After reposition of the joint surfaces and mechanical stabilisation, the defect is filled in with Ostim®. On account of its pasty consistency Ostim® is quickly converted into bone. An osseous formation is already visible after 3 months.

Fig. 3 shows an application of Ostim® in dental bone replacement.^[16]

{picture:P12;Fig. 3: Application of Ostim in dental bone grafting; ©Heraeus Kulzer GmbH;center}

PerOssal®

PerOssal® serves the permanent filling or reconstruction of osseous defects in casualty surgery, orthopaedics and oral and facial surgery. PerOssal® is a synthetic osseous substitute material with two prominent qualities. With PerOssal® an osseous substitute material is available which can also be introduced into infected osseous defects after preceding surgical cleaning of the wound with concurrent delivery of antibiotic. The second important quality is the quick and entire absorbance of PerOssal®. The component responsible for this is nanocrystalline Hydroxylapatite. The easy use of the product and the possibility of free combination with different active substances makes it attractive from an economic point of view.^[17]

Vitoss®

Vitoss® scaffold is a synthetic bone graft substitute for the repair of bony defects in the spine, extremities and pelvis. It is an osteo-conductive porous implant with a trabecular structure that resembles the multidirectional interconnected porosity of human cancellous bone. Vitoss® scaffold is composed of beta-tricalcium phosphate (ß-TCP) and guides the three-dimensional regeneration of bone in the defect site into which it is implanted and resorbed as new bone forms. Vitoss® has a similar architecture and chemical composition to natural bone mineral. High surface area and nanoparticulate structure enhances resorption. It promotes new bone ingrowth and maturation. Vitoss® is available in two convenient forms - blocks that can be shaped with a scalpel and gently tamped into place and morsels that can be packed into irregularly shaped voids in the defect site.

Fig. 4 shows an SEM-photograph of the Vitoss® bone void filler.^[18]

{picture:P13;Fig. 4: Vitoss® cancellous bone void filler; ©Orthovita, Inc.;center}